Selective loss of nigral neurons in Pick's disease: a morphometric study
Identifieur interne : 002754 ( Main/Exploration ); précédent : 002753; suivant : 002755Selective loss of nigral neurons in Pick's disease: a morphometric study
Auteurs : T. Uchihara [Japon] ; K. Tsuchiya [Japon] ; K. Kosaka [Japon]Source :
- Acta Neuropathologica [ 0001-6322 ] ; 1990-12-01.
Abstract
Summary: Loss of neurons from the substantia nigra (SN), which is often encountered in Pick's disease, was quantitatively analyzed in 13 cases of Pick's disease and 19 age-matched controls. On sections from the upper and lower portions of the SN, the pigmeted zone (zona compacta) and the non-pigmented zone (zona reticulata) were delineated, and these zones were partitioned into quarters: medial, mid-medial, mid-lateral and lateral. Neuronal loss was fairly severe and more evident in the upper section of the SN (−40%), especially in the midmedial and lateral quarters. In the lower section (neuronal loss:−28%), the medial quarter was most severely affected. Non-pigmented neurons were preserved. Fibrillary gliosis was denser in the zona reticulata, where neuronal loss was minimal. These findings revealed a selective vulnerability of nigral neurons according to their topography and pigmentation and suggests the primary involvement of some neuronal groups (especially the pigmented neurons) of the SN in Pick's disease.
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DOI: 10.1007/BF00334504
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Uchihara</name><affiliation wicri:level="3"><country xml:lang="fr">Japon</country><wicri:regionArea>Department of Neuropathology, Psychiatric Research Insitute of Tokyo, 2-1-8 Kamikitazawa, Setagaya-ku, 156, Tokyo</wicri:regionArea><placeName><settlement type="city">Tokyo</settlement></placeName></affiliation></author><author><name sortKey="Tsuchiya, K" sort="Tsuchiya, K" uniqKey="Tsuchiya K" first="K." last="Tsuchiya">K. Tsuchiya</name><affiliation wicri:level="3"><country xml:lang="fr">Japon</country><wicri:regionArea>Department of Neuropathology, Psychiatric Research Insitute of Tokyo, 2-1-8 Kamikitazawa, Setagaya-ku, 156, Tokyo</wicri:regionArea><placeName><settlement type="city">Tokyo</settlement></placeName></affiliation></author><author><name sortKey="Kosaka, K" sort="Kosaka, K" uniqKey="Kosaka K" first="K." last="Kosaka">K. Kosaka</name><affiliation wicri:level="3"><country xml:lang="fr">Japon</country><wicri:regionArea>Department of Neuropathology, Psychiatric Research Insitute of Tokyo, 2-1-8 Kamikitazawa, Setagaya-ku, 156, Tokyo</wicri:regionArea><placeName><settlement type="city">Tokyo</settlement></placeName></affiliation></author></analytic><monogr></monogr><series><title level="j">Acta Neuropathologica</title><title level="j" type="abbrev">Acta Neuropathol</title><idno type="ISSN">0001-6322</idno><idno type="eISSN">1432-0533</idno><imprint><publisher>Springer-Verlag</publisher><pubPlace>Berlin/Heidelberg</pubPlace><date type="published" when="1990-12-01">1990-12-01</date><biblScope unit="volume">81</biblScope><biblScope unit="issue">2</biblScope><biblScope unit="page" from="155">155</biblScope><biblScope unit="page" to="161">161</biblScope></imprint><idno type="ISSN">0001-6322</idno></series><idno type="istex">5E02C906BC0EC50A9D89F42B523A275A522263FA</idno><idno type="DOI">10.1007/BF00334504</idno><idno type="ArticleID">Art8</idno><idno type="ArticleID">BF00334504</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0001-6322</idno></seriesStmt></fileDesc><profileDesc><textClass></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Summary: Loss of neurons from the substantia nigra (SN), which is often encountered in Pick's disease, was quantitatively analyzed in 13 cases of Pick's disease and 19 age-matched controls. On sections from the upper and lower portions of the SN, the pigmeted zone (zona compacta) and the non-pigmented zone (zona reticulata) were delineated, and these zones were partitioned into quarters: medial, mid-medial, mid-lateral and lateral. Neuronal loss was fairly severe and more evident in the upper section of the SN (−40%), especially in the midmedial and lateral quarters. In the lower section (neuronal loss:−28%), the medial quarter was most severely affected. Non-pigmented neurons were preserved. Fibrillary gliosis was denser in the zona reticulata, where neuronal loss was minimal. These findings revealed a selective vulnerability of nigral neurons according to their topography and pigmentation and suggests the primary involvement of some neuronal groups (especially the pigmented neurons) of the SN in Pick's disease.</div></front></TEI><affiliations><list><country><li>Japon</li></country><settlement><li>Tokyo</li></settlement></list><tree><country name="Japon"><noRegion><name sortKey="Uchihara, T" sort="Uchihara, T" uniqKey="Uchihara T" first="T." last="Uchihara">T. Uchihara</name></noRegion><name sortKey="Kosaka, K" sort="Kosaka, K" uniqKey="Kosaka K" first="K." last="Kosaka">K. Kosaka</name><name sortKey="Tsuchiya, K" sort="Tsuchiya, K" uniqKey="Tsuchiya K" first="K." last="Tsuchiya">K. Tsuchiya</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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